The New York Times
People With Severe Diabetes Are Cured in Small Trial of New Drug
Sat, 21 Jun 2025 15:30:09 GMT
Vertex, like other drug companies, declined to announce the treatment’s cost before the Food and Drug Administration approves it.
A Vertex spokeswoman said the company had data only on the population it studied so it could not yet say whether the drug would help others with type 1 diabetes.
About two million Americans have type 1 diabetes, which is caused when the immune system destroys islet cells. A subset of islet cells, the beta cells, secrete insulin. Without insulin, glucose cannot enter cells. Patients with type 1 must inject carefully calibrated doses of the hormone to substitute for the insulin their body is missing.
Type 1 is different from the more common type 2 diabetes, which usually occurs later in life.
Controlling insulin levels is a constant, often costly effort. Elevated blood sugar levels can damage the heart, kidneys, eyes and nerves. But if levels fall too low, people can feel shaky, pass out or have seizures.
The patients in the study are among the estimated 30 percent with a complication of type 1 diabetes — hypoglycemic unawareness. Those with the condition have no warning when their glucose levels are falling precipitously. They lack the normal signs like shakiness or sweating that can signal a need for glucose.
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